You are hereHome › Usha Kundu, MD College of Health (UKCOH) › Department of Movement Sciences and Health › Lee, Youngil › Talin Style APAChicagoHarvardIEEEMLATurabian Choose the citation style. Campell, Z. K., Kwon, I., Finley, S. J., Lee, Y., & Javan, G. T. (2016). Talin: A potential protein biomarker in postmortem investigations. Journal of Forensic and Legal Medicine, 44, 188-191. doi:10.1016/j.jflm.2016.10.020 Talin Details Type Academic Journal Article Title Talin: A potential protein biomarker in postmortem investigations Contributor(s) Campell, Zahra K. (author)Kwon, Insu (author)Finley, Sheree J. (author)Lee, Youngil (author)Javan, Gulnaz T. (author) Located In Journal of Forensic and Legal Medicine ISSN 1752-928X Volume 44 Start Page 188 End Page 191 Date 2016 DOI 10.1016/j.jflm.2016.10.020 Use/Reproduction 2016 Elsevier Ltd and Faculty of Forensic and Legal Medicine Abstract The determination of the postmortem interval is of utmost importance in medicolegal death investigations. There are a number of ways to estimate the postmortem interval; however, the current established methods are susceptible to numerous biotic and abiotic factors. Previously published studies state that protein concentrations in postmortem brain tissues can detect protein changes via immunoblotting and densitometry techniques. The objective of the current study was to determine if there is a correlation between protein expression in cadaver tissues and postmortem interval. To this end, 18 brain tissues from cadavers from criminal cases were examined to determine how many hours after death the presence of four proteins (i.e., talin, α-enolase, cofilin-1, and vinculin) are detectable. Talin protein levels steadily decreased with increasing postmortem interval. Interestingly, the study demonstrated that talin protein levels were statistical significant between postmortem intervals of 24 versus 48 h and 24 versus 72 h by ANOVA. These results provide strong evidence that talin has potential to be used as a unique biomarker for the establishment of an additional method to estimate the time of death. Subject(s) Human brainTalinPostmortem intervalCadaver PID uwf:23867