Using phage to detect phospho-tau at position 217

Alzheimer's Disease (AD) remains mostly undiagnosed in the early stages of the disease.
• By the time that AD is clinically observed, it is thought that the damage done to the brain is too severe to be reversible.
• There is significant research suggesting AD-mediated changes to tau exist such as phosphorylation, oxidation, proteolysis and others
• Furthermore, recent data have shown that hyperphosphorylation on the tau protein is a critical post-translational modification (PTM) in AD that appear to manifest up to decades before clinical diagnosis.
• Specifically, tau phosphorylated at the 217-threonine position has shown promising results in other studies
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Abstract/Description: Alzheimer's Disease (AD) remains mostly undiagnosed in the early stages of the disease. • By the time that AD is clinically observed, it is thought that the damage done to the brain is too severe to be reversible. • There is significant research suggesting AD-mediated changes to tau exist such as phosphorylation, oxidation, proteolysis and others • Furthermore, recent data have shown that hyperphosphorylation on the tau protein is a critical post-translational modification (PTM) in AD that appear to manifest up to decades before clinical diagnosis. • Specifically, tau phosphorylated at the 217-threonine position has shown promising results in other studies
Subject(s): Position 217
Undergraduate Research
Alzheimer's Disease (AD)
Phospho-tau