SALDI-MS of real world samples

Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) is a method of mass spectrometry, ideal for the low mass range, as it reduces fragmentation and helps with clarity of sample analysis. Projected applications of this technology can be seen in medical and drug research.
• Quinine is a small, organic biomolecule (molecular weight 325 g/mol) that is derived from the bark of the cinchona plant. Native to the Americas, is historically used as an anti-malaria, but in recent years has emerged in drug analyses of heroin. Dealers dilute the sample in quinine, which has a similar bitter taste, as a way to conserve supply.
Due to its variety of functional groups and reactive units, quinine has many side effects. As of April 2019, the FDA limits quinine to 83ppm in beverage samples. Coupled with its increased use in illegal drugs and its regulated recreational use, a new, quick and easy method of detection is needed for its analysis.
• Quinine is commonly found dissolved in carbonated beverages to make tonic water.
• Transition metal oxide (TMOs) nanoparticles are used in SALDI-MS because they require minimal sample preparation, have large surface area to sample rations (which helps with desorption/ionization), and they are compatible with a wide range of different samples.
Download pdf
Abstract/Description: Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) is a method of mass spectrometry, ideal for the low mass range, as it reduces fragmentation and helps with clarity of sample analysis. Projected applications of this technology can be seen in medical and drug research. • Quinine is a small, organic biomolecule (molecular weight 325 g/mol) that is derived from the bark of the cinchona plant. Native to the Americas, is historically used as an anti-malaria, but in recent years has emerged in drug analyses of heroin. Dealers dilute the sample in quinine, which has a similar bitter taste, as a way to conserve supply. Due to its variety of functional groups and reactive units, quinine has many side effects. As of April 2019, the FDA limits quinine to 83ppm in beverage samples. Coupled with its increased use in illegal drugs and its regulated recreational use, a new, quick and easy method of detection is needed for its analysis. • Quinine is commonly found dissolved in carbonated beverages to make tonic water. • Transition metal oxide (TMOs) nanoparticles are used in SALDI-MS because they require minimal sample preparation, have large surface area to sample rations (which helps with desorption/ionization), and they are compatible with a wide range of different samples.
Subject(s): SALDI mass spectrometry
Undergraduate Research
Date Issued: 2021